Wenri H. Zhang

This study shows that stroke and Alzheimer's disease independently affect neurovascular function but together increase amyloid deposition in Tg2576 mice.

The paper introduces a novel mouse model of mild subcortical stroke and shows that astrogliosis spreads widely and independently of microglia and age.

This study identifies 20-HETE-dependent vasoconstriction as a mechanism impairing neurovascular coupling after stroke, showing that inhibiting its synthesis can restore blood flow in peri-infarct regions.

The paper introduces sciMAP-ATAC, a method for spatially resolved single-cell chromatin accessibility profiling, and applies it to study cortical lamination, spatial trajectories, and ischemic infarct progression in mouse and human tissues.

The paper examines GPR39 localization in aged human brains and correlates its expression and polymorphism with vascular cognitive impairment.