Glypican-1 upregulation elicited in response to a cell-impermeable kinase inhibitor and its overexpression enhance HIV-1 infection
Kelsey Vinzant, Natalia Cheshenko, Heng Pan, Ronald R. Cutler, Joshua N. Buckler, Andreas Luxenburger, Lawrence D. Harris, Jeffrey R. Johnson, Steven C. Almo, Betsy C. Herold
The paper identifies glypican-1 (GPC1) as a novel modulator of HIV-1 infection, showing its upregulation by a kinase inhibitor enhances viral infection through TGF-β signaling.
bioRxiv · Oct 28, 2025 · PreprintMicrobiology