Morten Beck Rye

This study integrates DNA methylation, gene expression, and metabolic profiles to identify molecular pathways and signatures associated with aggressive prostate cancer and disease recurrence.

The paper identifies molecular signatures in prostate cancer that link inflammatory chemokine expression to metabolic changes and relapse risk.

The paper introduces MIIT, a toolset for integrating spatial multi-omics data, and validates its registration algorithm on serial tissue sections.

The paper uses FunHoP to analyze mitochondrial gene expression in prostate cancer, finding upregulation of mitochondrial pathways in cancerous cells compared to normal cells.

The paper identifies a gene signature associated with citrate and spermine secretion in prostate epithelial cells and shows its expression decreases in aggressive prostate cancer.

This study identifies LSD1 as a repressor of a neonatal/reparative gene program in adult intestinal epithelium, showing its role in Paneth cell differentiation and regenerative capacity.

MACPET analyzes ChIA-PET data to find protein binding sites with improved motif occurrence, spatial resolution, and false discovery rate compared to MACS.