Menno J. Oudhoff

Prostaglandin E2 facilitates reciprocal crosstalk between intestinal smooth muscle tissue and epithelium in tumor development

The paper identifies Prostaglandin E2 as a key mediator of crosstalk between intestinal smooth muscle tissue and epithelium in tumor development, showing reciprocal effects on both cell types.

Fetal-like reversion in the regenerating intestine is regulated by mesenchymal Asporin

The paper shows that mesenchymal Asporin mediates fetal-like reprogramming in regenerating intestinal epithelium by modulating Tgfβ signaling through CD44.

Maternal type 2 immunity promotes a microchimeric transfer of systemic type 2 immunity to offspring.

This study shows maternal type 2 immunity, independent of antigen exposure, transfers protective immunity to offspring via microchimeric cells.

Intestinal-epithelial LSD1 controls cytoskeletal-mediated cell identity including goblet cell effector responses required for gut inflammatory and infectious diseases

This study shows that intestinal-epithelial LSD1 deletion leads to increased pathogenesis in inflammatory and infectious disease models by impairing cytoskeletal organization and goblet cell effector responses.

LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium

This study identifies LSD1 as a repressor of a neonatal/reparative gene program in adult intestinal epithelium, showing its role in Paneth cell differentiation and regenerative capacity.