Eugenia Galeota

CIA provides a reference-free method for cell type annotation in scRNA-seq data, outperforming existing approaches with lower computational cost.

This study identifies EOMES+Tr1-like regulatory T-cells in MS that produce IL-10 and are activated by EBV, suggesting their impaired function contributes to immune escape.

The paper introduces INSPEcT-, a computational method to infer RNA synthesis, processing, and degradation dynamics from total RNA data without metabolic labeling, and applies it to study post-transcriptional regulation in various conditions.