Author

Sergio Abrignani

University of MilanORCID 0000-0002-0794-3285Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:flow cytometry· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2

Frequent Co-Authors

Chiara VascoiD· 2 shared Eugenia GaleotaiD· 2 shared Francesca ClementeiD· 2 shared Ivan FerrariiD· 2 shared Jens GeginatiD· 2 shared Mariacristina CrostiiD· 2 shared Nadia PulvirentiiD· 2 shared Renata GrifantiniiD· 2 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

Chiara VascoORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

AD-HIES patients retain preTh17-cells that produce IL10 with opportunistic pathogens and induce IgE

Giorgia Moschetti, Chiara Vasco, Francesca Clemente, Paola Larghi, Sara Maioli, Edoardo Scarpa, Elena Carelli, Nadia Pulvirenti, Maria Lucia Sarnicola, Mariacristina Crosti, Manal Bel Imam, Willem van de Veen, Loris Rizzello, Sergio Abrignani, Lucia Augusta Baselli, , Jens Geginat

The paper identifies IL-10-producing pre-Th17 cells in AD-HIES patients that respond to pathogens and support IgE production despite STAT3 mutations.

Allergy · Feb 25, 2026Peer-reviewedImmunology

CIA: a Clustering Independent Annotation method to investigate cell identities in scRNA-seq data

Ivan Ferrari, Mattia Battistella, Francesca Vincenti, Andrea Gobbini, Fédérico Marini, Samuele Notarbartolo, Jole Costanza, Stefano Biffo, Renata Grifantini, Sergio Abrignani, Eugenia Galeota

CIA provides a reference-free method for cell type annotation in scRNA-seq data, outperforming existing approaches with lower computational cost.

BMC Bioinformatics · Dec 17, 2025Peer-reviewedBioinformatics

Regulatory T-cells in multiple sclerosis produce IL-10 in the central nervous system but are activated by Epstein-Barr Virus

Nadia Pulvirenti, C. Righetti, Francesca Clemente, Barbara Serafini, Chiara Cordiglieri, Chiara Vasco, S. Maioli, Anna Margherita Pietroboni, Eugenia Galeota, Barbara Rosicarelli, Claudia Iannone, Milena Alessandra De Riz, Alejandro Espadas de Arias, Tullia De Feo, Luca V. C. Valenti, , Jens Geginat

This study identifies EOMES+Tr1-like regulatory T-cells in MS that produce IL-10 and are activated by EBV, suggesting their impaired function contributes to immune escape.

bioRxiv · Jul 30, 2024 · PreprintImmunology

Combiroc: when 'less is more' in bulk and single cell marker signatures.

Ivan Ferrari, Saveria Mazzara, Mariacristina Crosti, Sergio Abrignani, Renata Grifantini, Mauro Bombaci, Riccardo Lorenzo Rossi

Combiroc refines marker signatures by selecting smaller, more discriminative subsets from scRNA-seq data, validated against independent datasets and the human protein atlas.

bioRxiv · Jan 17, 2022 · PreprintBioinformatics