Mattia Pelizzola

The paper investigates how centrosome architecture and m6A-dependent regulation influence p53 surveillance after whole-genome doubling, identifying key molecular mechanisms.

The paper introduces an IVT-based method with dRNA-seq to detect RNA modifications across the transcriptome, identifying 26,619 modification sites and revealing non-random co-occurrence and isoform-specific patterns.

The paper shows that translation is required for miRNA-dependent transcript decay, as non-translated lncRNAs are minimally affected by miRNA loss, while translated transcripts are destabilized.

The paper introduces INSPEcT-, a computational method to infer RNA synthesis, processing, and degradation dynamics from total RNA data without metabolic labeling, and applies it to study post-transcriptional regulation in various conditions.

The paper analyzes DNA methylation dynamics in the mouse auditory organ of Corti during development and maturation, identifying novel regulatory regions and candidate factors involved in inner ear development.

The paper classifies human coding and non-coding genes based on RNA metabolism profiles, revealing distinct metabolic patterns and functional subsets of lncRNAs.