Jeff J. Sekelsky

The paper investigates chromosome-specific differences in recombination patterns associated with meiotic nondisjunction in Drosophila, finding reduced recombination in chromosome 2 compared to the X chromosome.

The paper investigates crossover suppression in Drosophila pericentromeric regions by analyzing mutations affecting the synaptonemal complex and recombination factors, finding that these factors are critical for suppressing crossovers in heterochromatin.

The paper investigates the functional roles of the N-terminal intrinsically disordered region of Bloom Syndrome helicase in Drosophila by deleting conserved regions and assessing their impact on DNA repair and meiotic processes.

This study investigates the robustness of the Drosophila centromere effect to changes in centromere number and repetitive DNA content, finding it to be resilient to these factors.

This study investigates how repeat length affects Marcal1-dependent single-strand annealing in Drosophila, finding that 500-2000 bp is needed for maximum efficiency and that Marcal1 dynamics influence SSA rates.

This study shows that Blm helicase is essential for managing replication stress during early Drosophila development by facilitating replication through repetitive DNA sequences in syncytial cell cycles.

This paper shows that DNA polymerase theta compensates for the loss of Holliday junction resolvases by suppressing mitotic crossing over and maintaining genomic stability.

The paper describes a backup repair mechanism in Drosophila meiosis where non-homologous end joining (NHEJ) precisely repairs resected meiotic DSBs when homologous recombination fails.

This study elucidates how DNA Polymerase Theta identifies microhomologies during repair and shows how this process leads to genomic scars in cancer.

The paper identifies Mus302 as the Drosophila ortholog of RFWD3 and shows it does not function in DNA repair like its human counterpart.

The paper maps centromere-proximal crossovers in Drosophila melanogaster and identifies two mechanisms suppressing crossovers: HR-heterochromatin and the centromere effect.

This study investigates how specific regions and motifs of mei-MCM proteins influence Class I and II crossover formation in Drosophila.

The paper investigates meiotic crossover patterning in Drosophila mei-41 null mutants, finding reduced crossover levels and loss of interference but preserved centromere effect.