Author
University of North Carolina at Chapel HillORCID 0000-0003-1575-4748Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Niphat Jirapongwattana, Carley M. Conover, Catalina Trujillo Jaramillo…·Adam R. Karpf
This study identifies a RHNO1-ATR/Chk1 positive feedback loop that sustains DNA replication stress response and highlights RHNO1 as a therapeutic target in cancer.
Oliver W. Chung, Shun Yao, Ling Wang…·ZZ Zhao Zhang
This study identifies BRCA1-A and LIG4 complexes as mediators of ecDNA biogenesis and shows their role in cancer drug resistance.
Chelsea M. Smith, Dennis A. Simpson, Paolo Guerra…·Gaorav P. Gupta
The paper shows Pol{theta} is recruited via RAD51 ubiquitylation to resolve clustered ICLs causing replication fork collapse in HR-proficient cells.
Juan Carvajal-Garcia, K. Nicole Crown, Dale A. Ramsden, Jeff J. Sekelsky
This paper shows that DNA polymerase theta compensates for the loss of Holliday junction resolvases by suppressing mitotic crossing over and maintaining genomic stability.
Juan Carvajal-Garcia, Jang-Eun Cho, Pablo Carvajal-Garcia…·Dale A. Ramsden
This study elucidates how DNA Polymerase Theta identifies microhomologies during repair and shows how this process leads to genomic scars in cancer.
Juan Carvajal-Garcia, Evan R. Gales, Dale A. Ramsden, Jeff J. Sekelsky
The paper identifies Mus302 as the Drosophila ortholog of RFWD3 and shows it does not function in DNA repair like its human counterpart.