Cell BiologybioRxivPreprint
Repurposing of the assembly chaperone PAC1-PAC2 defines a specialized proteasome landscape in mature mammalian sperm
Xuehai Zhou, Linlin Shen, Xuyang Yuan…·Yao Cong
This study identifies a specialized proteasome structure in mature mammalian sperm using cryo-EM, revealing that PAC1/2 repurposes from a chaperone to a stable regulator, defining a hyperactive 20S variant.