Yao Cong

This study elucidates the TRiC-assisted folding of class I HDACs, revealing distinct co-chaperone and cofactor networks for HDAC1 and HDAC3, while HDAC8 folds independently.

This study identifies a specialized proteasome structure in mature mammalian sperm using cryo-EM, revealing that PAC1/2 repurposes from a chaperone to a stable regulator, defining a hyperactive 20S variant.

The paper identifies TRiC/CCT as a chaperonin in mammalian sperm flagella that folds locally translated proteins, supporting flagellar function and fertility.

This study reveals how TRiC folds the large ciliary protein IFT172 using a non-canonical open-state mechanism involving Z-shaped bending and fold-and-eject dynamics.

This study investigates how LCA-linked mutations in TRiC/CCT subunit CCT2 disrupt its allosteric network and functional cycle, leading to structural and functional defects associated with Leber Congenital Amaurosis.

This study reveals the mechanism by which the 26S proteasome recognizes and degrades ODC without ubiquitin, through cryo-EM structures showing dynamic interactions and translocation processes.

This study uses cryo-EM to reveal conformational dynamics of SARS-CoV-2 spike trimer in complex with ACE2, showing how ACE2 binding triggers structural changes and enhanced infectivity.