This study shows that synaptopodin and the spine apparatus organelle are essential for lesion-induced synaptic plasticity at hippocampal mossy fiber synapses in mice.

Cells · Jan 6, 2024Peer-reviewedNeuroscience

Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease

Erik Schäffner, Mar Bosch-Queralt, Julia M. Edgar, Maria Lehning, Judith Strauß, Niko Fleischer, Theresa Kungl, Peter Wieghofer, Stefan A. Berghoff, T. Reinert, Martin Krueger, Markus Morawski, Wiebke Möbius, Alonso Barrantes‐Freer, Jens Stieler, , Ruth Martha Stassart

The paper challenges the view that axonal degeneration in MS results from immune-mediated damage by proposing that myelin itself increases axonal degeneration risk under inflammatory conditions.

Nature Neuroscience · Jun 29, 2023Peer-reviewedNeuroscience

Myelin biogenesis is associated with pathological ultrastructure that is resolved by microglia during development

Minou Djannatian, Ulrich Weikert, Shima Safaiyan, Christoph Wrede, Cassandra Deichsel, Georg Kislinger, Torben Ruhwedel, Douglas S. Campbell, Tjakko J. van Ham, Bettina Schmid, Jan Hegermann, Wiebke Möbius, Martina Schifferer, Mikael Simons

The paper investigates myelin structural changes during development in mice and zebrafish, finding that myelin degeneration is resolved by microglia, while sheath retractions occur independently.

bioRxiv · Feb 2, 2021 · PreprintNeuroscience