Author

Martin Høgholm Jørgensen

Aarhus UniversityORCID 0000-0002-4459-5523Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Ana V. AlmeidaiD· 1 shared Birthe Brandt KragelundiD· 1 shared Emil E. TranchantiD· 1 shared Gregers Rom AnderseniD· 1 shared Heidi Gytz OleseniD· 1 shared Henrik PederseniD· 1 shared Ida B. Thøgersen· 1 shared Jan J. EnghildiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Ana V. AlmeidaORCID

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1 paper

Recent·Most cited

Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring

Trine Amalie Fogh Gadeberg, Martin Høgholm Jørgensen, Heidi Gytz Olesen, Josefine Lorentzen, Seandean L. Harwood, Ana V. Almeida, Marlene Uglebjerg Fruergaard, Rasmus K. Jensen, Philipp Kanis, Henrik Pedersen, Emil E. Tranchant, Steen Vang Petersen, Ida B. Thøgersen, Birthe Brandt Kragelund, Joseph Anthony Lyons, , Gregers Rom Andersen

This study uses cryo-EM to analyze the structural changes in C3 during hydrolysis, revealing a dynamic opening in the macroglobulin ring that allows domain translocation.

Nature Structural & Molecular Biology · Jan 23, 2025Peer-reviewedBiochemistry