Jenna E. Haines

The paper develops a method to generate variant libraries in vivo using base editing to study gene regulatory programs in multicellular organisms.

The paper investigates whether chromatin accessibility in early Drosophila embryos is driven by transcriptional activity or independent mechanisms, finding that accessibility is largely uniform and not directly linked to activity.

The paper maps chromatin contacts in Drosophila embryos to show that insulator boundaries align with polytene interbands and TADs.

The paper uses live imaging in Drosophila embryos to show that Bicoid binds DNA with a rapid off-rate and forms localized hubs that enable concentration-sensitive regulation.