Author

Amanda L. Waterbury

Broad InstituteORCID 0000-0002-4473-2866Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Brian B. LiauiD· 2 shared Ceejay LeeiD· 2 shared Allison P. SiegenfeldiD· 1 shared Andrea MatteviiD· 1 shared Eunju NamiD· 1 shared Haibin MaoiD· 1 shared Hanjie JiangiD· 1 shared Hui Si KwokiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersGenomics

Brian B. LiauORCID

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2 papers

Recent·Most cited

GenomicseLifePeer-reviewedSep 3, 2025

DNA methylation insulates genic regions from CTCF loops near nuclear speckles

Shelby A Roseman, Allison P. Siegenfeld, Ceejay Lee…·Brian B. Liau

The paper investigates how DNA methylation affects CTCF-mediated chromatin loops and gene expression by using DNMT1 inhibition and targeted protein degradation.

13 citations

humanDNA methylation

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Molecular BiologyNaturePeer-reviewedFeb 12, 2025

Asymmetric Engagement of Dimeric CRL3KBTBD4 by the Molecular Glue UM171 Licenses Degradation of HDAC1/2 Complexes

Megan J. R. Yeo, Olivia Zhang, Xiaowen Xie…·Ning Zheng

This paper identifies UM171 as a molecular glue that promotes degradation of HDAC1/2 complexes by inducing asymmetric interactions between KBTBD4 and HDAC1.

59 citationstop 1%

humanproteomics

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