Author
Brigham and Women's HospitalORCID 0000-0001-6090-4552Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Robert J. Fisher, Kihyun Park, Kwangwoon Lee…·Rhoda M. Alani
The paper shows that inhibiting the CoREST complex with corin alters RNA splicing, increases neoantigen expression, and enhances tumor immunity in melanoma.
Sukjin S. Jang, Sasha A.T. McDowell, Pramod KC…·Josefina Inés del Mármol
This paper decodes the structural logic of pheromone recognition in silkmoths to design small molecules that disrupt insect mating behavior.
Megan J. R. Yeo, Olivia Zhang, Xiaowen Xie…·Ning Zheng
This paper identifies UM171 as a molecular glue that promotes degradation of HDAC1/2 complexes by inducing asymmetric interactions between KBTBD4 and HDAC1.
Xiaowen Xie, Olivia Zhang, Megan J. R. Yeo…·Brian B. Liau
This study identifies how KBTBD4 cancer mutations drive neomorphic interactions with HDAC1/2, leading to CoREST degradation and tumor growth, and shows potential therapeutic strategies.
Ruili Cao, Oren Gozlan, Alina Airich…·Stephen C. Blacklow
This study identifies the structural requirements of MIB1 for ubiquitin transfer in Notch signaling, showing that RING3 is essential for catalytic activity and dimerization.
Arian Mansur, Remi Joseph, Euri S Kim…·Vandana Gupta
This study identifies KLHL40 as a negative regulator of ER-Golgi trafficking through ubiquitylation, revealing its role in skeletal muscle development and disease.