Megan J. R. Yeo

Asymmetric Engagement of Dimeric CRL3KBTBD4 by the Molecular Glue UM171 Licenses Degradation of HDAC1/2 Complexes

This paper identifies UM171 as a molecular glue that promotes degradation of HDAC1/2 complexes by inducing asymmetric interactions between KBTBD4 and HDAC1.

KBTBD4 Cancer Hotspot Mutations Drive Neomorphic Degradation of HDAC1/2 Corepressor Complexes

This study identifies how KBTBD4 cancer mutations drive neomorphic interactions with HDAC1/2, leading to CoREST degradation and tumor growth, and shows potential therapeutic strategies.

Profiling the Landscape of Drug Resistance Mutations in Neosubstrates to Molecular Glue Degraders

This study identifies drug resistance mutations in neosubstrates of molecular glue degraders using CRISPR-suppressor scanning and reveals common resistance mechanisms.

A facile platform to engineer E. coli tyrosyl-tRNA synthetase adds new chemistries to the eukaryotic genetic code, including a phosphotyrosine mimic

This paper describes an engineered E. coli tyrosyl-tRNA synthetase system that enables the incorporation of new noncanonical amino acids into eukaryotic cells.

Structural robustness affects the engineerability of aminoacyl-tRNA synthetases for genetic code expansion

The paper shows that structural robustness of tyrosyl-tRNA synthetases affects their ability to be engineered for genetic code expansion, with MjTyrRS being more robust than EcTyrRS.