Andrew John Brown

Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase

The paper shows hypoxia triggers truncation and constitutive activation of squalene monooxygenase (SM) through proteasomal targeting and substrate accumulation, linking it to oncogenic properties in endometrial cancer.

The mammalian cholesterol synthesis enzyme squalene monooxygenase is proteasomally truncated to a constitutively active form

This paper identifies a proteasomally truncated form of the cholesterol synthesis enzyme SM that is constitutively active and resistant to cholesterol-induced degradation.