Author

Hudson W. Coates

University of CambridgeORCID 0000-0002-6506-5249Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrew John BrowniD· 2 shared Isabelle M. Capell-HattamiD· 2 shared James A. NathaniD· 2 shared Niek WitiD· 2 shared Anneliese O. SpeakiD· 1 shared Anthony W. MartinelliiD· 1 shared Arthur KaseriD· 1 shared Chun-Pei Wu· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersMolecular Biology

Andrew John BrownORCID

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Author profile →

4 papers

Recent·Most cited

Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux.

Anthony W. Martinelli, Chun-Pei Wu, Tristan Vornbäumen, Hudson W. Coates, Louise Jordon, Niek Wit, Jia Jhing Sia, Anneliese O. Speak, James A. Nathan

The paper identifies SETD2 as a regulator of iron metabolism by modulating ferritin breakdown, affecting cellular iron levels and ferroptosis resistance.

Science Advances · Sep 17, 2025Peer-reviewedCell Biology

ABHD11 mediated deglutarylation regulates the TCA cycle and T cell metabolism

Guinevere L. Grice, Eleanor Minogue, Hudson W. Coates, Mekdes Debela, Richard J Stopforth, Niek Wit, Zongyu Li, Joseph P. Crowley, Arthur Kaser, Nicole Kaneider-Kaser, Robin Antrobus, Marcia C. Haigis, Randall S. Johnson, James A. Nathan

This study identifies ABHD11 as a deglutarylating enzyme that regulates T cell metabolism by maintaining TCA cycle integrity through removal of glutaryl-lipoyl adducts.

Nature Chemical Biology · Jul 15, 2025Peer-reviewedCell Biology

Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase

Hudson W. Coates, Isabelle M. Capell-Hattam, Ellen M. Olzomer, Ximing Du, Rhonda Farrell, Hongyuan Yang, Frances L. Byrne, Andrew John Brown

The paper shows hypoxia triggers truncation and constitutive activation of squalene monooxygenase (SM) through proteasomal targeting and substrate accumulation, linking it to oncogenic properties in endometrial cancer.

eLife · Dec 13, 2022Peer-reviewedMolecular Biology

The mammalian cholesterol synthesis enzyme squalene monooxygenase is proteasomally truncated to a constitutively active form

Hudson W. Coates, Isabelle M. Capell-Hattam, Andrew John Brown

This paper identifies a proteasomally truncated form of the cholesterol synthesis enzyme SM that is constitutively active and resistant to cholesterol-induced degradation.

Journal of Biological Chemistry · Jan 1, 2021Peer-reviewedMolecular Biology