Author

Frances L. Byrne

UNSW SydneyORCID 0000-0002-8897-8438Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Andrew John BrowniD· 1 shared Ellen M. OlzomeriD· 1 shared Hongyuan YangiD· 1 shared Hudson W. CoatesiD· 1 shared Isabelle M. Capell-HattamiD· 1 shared Rhonda FarrelliD· 1 shared Ximing DuiD· 1 shared

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2022-2022 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Andrew John BrownORCID

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1 paper

Recent·Most cited

Molecular BiologyeLifePeer-reviewedDec 13, 2022

Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase

Hudson W. Coates, Isabelle M. Capell-Hattam, Ellen M. Olzomer…·Andrew John Brown

The paper shows hypoxia triggers truncation and constitutive activation of squalene monooxygenase (SM) through proteasomal targeting and substrate accumulation, linking it to oncogenic properties in endometrial cancer.

18 citations

humanexperimental assay

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