Author

Léa Gaucherand

Centre National de la Recherche ScientifiqueORCID 0000-0002-4477-1021Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Sébastien PfefferiD· 3 shared Amandine Le Corf· 1 shared Béatrice Chane-Woon-Ming· 1 shared Carine ReyiD· 1 shared Clara Loyer· 1 shared Dakota McMillan· 1 shared David EnardiD· 1 shared Devaughn L. FraseriD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersMicrobiology

Sébastien PfefferORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

MicrobiologyPLoS PathogensPeer-reviewedDec 22, 2025

Dicer accumulates in cytoplasmic foci upon alphavirus infection and plays a proviral role in Myotis myotis bat cells

Léa Gaucherand, Hugo Marie, Julie Cremaschi, Sébastien Pfeffer

This study shows Dicer promotes alphavirus replication in Myotis myotis bat cells by relocalizing to cytoplasmic foci containing viral RNA.

DOI 10.1371/journal.ppat.1013815

mouseexperimental assay

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GenomicsbioRxivPreprintOct 10, 2024

Extensive longevity and DNA virus-driven adaptation in nearctic Myotis bats

Juan Manuel Vázquez, M. Elise Lauterbur, Saba Mottaghinia…·Peter H. Sudmant

This study identifies genetic adaptations in Myotis bats linked to longevity and viral tolerance through genome analysis and functional experiments.

11 citations

mousewhole-genome sequencing

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Molecular BiologyThe EMBO JournalPeer-reviewedJan 29, 2024

Non-canonical contribution of human Dicer helicase domain in antiviral innate immune response

Morgane Baldaccini, Léa Gaucherand, Béatrice Chane-Woon-Ming…·Sébastien Pfeffer

The paper investigates the role of Dicer's helicase domain in antiviral immunity, finding that a truncated mutant acts RNAi-independently via PKR and NF-kB pathways.

17 citations

humanstatistical model

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