Sébastien Pfeffer

Field-isolate recombinant tick-borne encephalitis viruses define reporter-stability guidelines for antiviral testing in flaviviruses

This paper develops recombinant tick-borne encephalitis viruses with reporter genes to guide antiviral testing, finding that Nluc is more stable than eGFP in certain conditions.

Dicer accumulates in cytoplasmic foci upon alphavirus infection and plays a proviral role in Myotis myotis bat cells

This study shows Dicer promotes alphavirus replication in Myotis myotis bat cells by relocalizing to cytoplasmic foci containing viral RNA.

Fatty Acid Synthase associates with nuclear-derived cytoplasmic dsRNA molecules and influences antiviral innate immune response

This study shows FASN depletion increases cytoplasmic endogenous dsRNA and enhances antiviral innate immune responses.

Extensive longevity and DNA virus-driven adaptation in nearctic Myotis bats

This study identifies genetic adaptations in Myotis bats linked to longevity and viral tolerance through genome analysis and functional experiments.

Non-canonical contribution of human Dicer helicase domain in antiviral innate immune response

The paper investigates the role of Dicer's helicase domain in antiviral immunity, finding that a truncated mutant acts RNAi-independently via PKR and NF-kB pathways.

Cis regulation within a cluster of viral microRNAs

The paper investigates cis regulation of viral microRNA clusters in KSHV, showing that specific pre-miRNAs influence the expression of the entire cluster and can be targeted to inhibit miRNA production.

High-throughput fluorescence-based screen identifies the neuronal microRNA miR-124 as a positive regulator of alphavirus infection

The paper identifies miR-124 as a positive regulator of alphavirus infection through a genome-wide miRNA screen and shows its direct interaction with viral RNA.