Subrata Paul

This study shows that activated PI3Kdelta reduces TCF-1+ stem-like CD8+ T cells but promotes effector differentiation and viral control during chronic infection.

The paper identifies a novel PIK3R1 frameshift mutation linked to immunodeficiency and ALS, showing haploinsufficiency causes neuronal dysfunction and apoptosis.

The paper introduces a mixture model for case-control studies to account for disease heterogeneity, showing reduced bias in odds ratio estimates compared to standard logistic regression.