Author

Steven P. Seegobin

Icahn School of Medicine at Mount SinaiORCID 0000-0002-4514-9293Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Bin ZhangiD· 1 shared Insup ChoiiD· 1 shared Kerry PurtelliD· 1 shared Mathilde PruvostiD· 1 shared Qian WangiD· 1 shared Yuanxi ZhangiD· 1 shared Zhenyu YueiD· 1 shared

Activity by Year

2020-2020 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Bin ZhangORCID

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1 paper

Recent·Most cited

Microglia Clear Neuron-released α-Synuclein via Selective Autophagy and Prevent Neurodegeneration

Insup Choi, Yuanxi Zhang, Steven P. Seegobin, Mathilde Pruvost, Qian Wang, Kerry Purtell, Bin Zhang, Zhenyu Yue

This study identifies a novel neuroprotective mechanism where microglia clear neuron-released α-synuclein via TLR4-NF-κB-p62 mediated selective autophagy, preventing neurodegeneration.

Nature Communications · Mar 13, 2020Peer-reviewedNeuroscience