Insup Choi

This study identifies RAB12 as a LRRK2 substrate in mouse brains, shows its role in suppressing ciliogenesis and regulating centrosome homeostasis in astrocytes, and demonstrates that disrupting RAB12 mitigates PD-linked LRRK2 mutation effects.

This study generates a large single-cell RNA sequencing dataset of the human substantia nigra in Parkinson's disease, identifies DA neuron subtypes, and reveals molecular changes associated with PD.

This study identifies a novel neuroprotective mechanism where microglia clear neuron-released α-synuclein via TLR4-NF-κB-p62 mediated selective autophagy, preventing neurodegeneration.