Qian Wang

This study shows that DUSP6 overexpression in the dorsal hippocampus of male 5xFAD mice reduces amyloid load and improves memory, while also reducing neuroinflammation in both sexes.

The paper uses integrated proteomics to identify autophagy targets and receptors in human neurons, revealing their role in degradation and neuronal activity regulation.

This study generates a large single-cell RNA sequencing dataset of the human substantia nigra in Parkinson's disease, identifies DA neuron subtypes, and reveals molecular changes associated with PD.

This study analyzes the tissue-specific age dependence of cell receptors involved in SARS-CoV-2 infection and identifies key regulators and host processes hijacked by the virus.

This study identifies a novel neuroprotective mechanism where microglia clear neuron-released α-synuclein via TLR4-NF-κB-p62 mediated selective autophagy, preventing neurodegeneration.

This study identifies molecular networks and key regulators in Alzheimer’s Disease using integrative genomics and experimental validation.

This study shows that reduced SYNJ1 expression with age contributes to dopamine neuron vulnerability and Parkinson's disease pathogenesis in mice.