Maria A. Andrianova

Segregating DNA lesions point to high selective advantage of tumor initiating cells

The paper uses DNA lesion segregation to estimate tumor initiating events and shows early cancer drivers have a fitness advantage exceeding 30%.

Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis

The paper develops machine learning models to identify clonal hematopoiesis driver mutations, outperforming existing methods and applying them to UK Biobank data to confirm known associations.

Extended family with an inherited pathogenic variant in polymerase delta provides strong evidence for recessive effect of proofreading deficiency in human cells

The paper investigates the effect of an inherited POLD1 variant on mutation rates in germline and somatic cells, showing a recessive effect on proofreading deficiency in cancer.

POLD replicates both strands of small kilobase-long replication bubbles initiated at a majority of human replication origins

The paper shows POLD1 replicates both strands within 1 kb of replication origins, with mutational bias indicating most origins fire and only a quarter result in processive forks.

APOBEC3A/B-induced mutagenesis is responsible for 20% of heritable mutations in the TpCpW context

The paper shows APOBEC3A/B causes 20% of heritable C→T and C→G mutations in humans, preferentially on the lagging strand.