Georgii A. Bazykin

This study shows that antigenic selection of influenza virus within hosts is driven by immune pressure timing and fitness tradeoffs, with moderate stochastic effects observed.

The paper quantifies mutation bias in driver genes to estimate the number of driver mutations and their effect distribution across oncogenes and tumor-suppressor genes.

EpiPAMPAS detects intra-protein epistasis by analyzing multiple sequence alignments and finds interactions with low p-values in simulated and real viral protein data.

The paper investigates the role of mitochondrial DNA repeats in aging and healthspan, finding that disrupting the common repeat reduces somatic deletions and improves healthspan.

The paper identifies a contact zone in the human mitochondrial genome where deletions are more likely, linking it to aging and lifespan.

The paper investigates the effect of an inherited POLD1 variant on mutation rates in germline and somatic cells, showing a recessive effect on proofreading deficiency in cancer.

This study analyzes the genomic features of the SARS-CoV-2 Omicron variant, identifying its high mutation rate, spike protein alterations, and distinct evolutionary patterns.

The paper investigates whether convergent evolution occurs in mitochondrial genomes of birds under similar environmental pressures and finds most convergence events are likely random.

The paper presents methods to improve fetal variant calling accuracy in the presence of maternal cell contamination using Bayesian models and learned genotype-correction models.

This study analyzes the genome of Adineta vaga to show that recombination occurs despite the absence of meiosis, suggesting a mechanism for genetic exchange in asexual populations.

The paper shows POLD1 replicates both strands within 1 kb of replication origins, with mutational bias indicating most origins fire and only a quarter result in processive forks.

The paper measures homoplasies in mitochondrial proteins across metazoan species and finds that parallel substitutions occur at shorter phylogenetic distances than divergent substitutions.

The paper shows APOBEC3A/B causes 20% of heritable C→T and C→G mutations in humans, preferentially on the lagging strand.