Artem V. Artemov

Unbiased profiling of multipotency landscapes reveals spatial modulators of clonal fate biases

The paper profiles clonal landscapes in mouse embryos to reveal spatial modulators of clonal fate biases using single-cell lineage tracing and clone2vec.

A branching model of cell fate decisions in the enteric nervous system

The paper maps the regulatory landscape of neuronal and glial differentiation in the enteric nervous system using single-cell RNA sequencing and identifies gene modules and epigenetic memory associated with neurogenesis and gliogenesis.

POLD replicates both strands of small kilobase-long replication bubbles initiated at a majority of human replication origins

The paper shows POLD1 replicates both strands within 1 kb of replication origins, with mutational bias indicating most origins fire and only a quarter result in processive forks.

CpG traffic lights are markers of regulatory regions in humans

The paper identifies CpG traffic lights as markers of regulatory regions by showing their correlation with gene expression and evolutionary conservation.

Integrated deep learned transcriptomic and structure-based predictor of clinical trials outcomes

The paper develops a deep learning pipeline to predict clinical trial outcomes using transcriptomic data, achieving 83% cross-validated accuracy and outperforming gene-based classifiers.