Vanessa M. Hayes

Methylation reprogramming associated with aggressive prostate cancer and ancestral disparities

The paper investigates DNA methylation differences in prostate cancer across African, European, and Asian ancestries, finding ancestry-driven methylation patterns linked to disease aggressiveness in African tumors.

Identifying Rare Germline Variants Associated with Metastatic Prostate Cancer Through an Extreme Phenotype Study

This study identifies rare germline variants associated with metastatic prostate cancer using an extreme phenotype cohort and validates their functional impact.

Multiomic Insights into Human Health: Gut Microbiomes of Hunter-Gatherer, Agropastoral, and Western Urban Populations

This study compares the gut microbiomes of Ju/hoansi hunter-gatherers, agropastoralists, and Western urban populations, finding higher diversity and health-associated pathways in the former.

The Australasian dingo archetype: De novo chromosome-length genome assembly, DNA methylome, and cranial morphology

The paper presents a high-quality chromosome-level genome assembly, DNA methylome, and cranial morphology analysis of an Alpine dingo, supporting its status as an archetype for evolutionary studies.

Shiny-SoSV: A web-based performance calculator for somatic structural variant detection

Shiny-SoSV predicts the performance of somatic structural variant detection based on parameters like sequencing depth and variant allele fraction.

Detection of somatic structural variants from short-read next-generation sequencing data

This paper reviews eight somatic structural variant callers, evaluating their sensitivity and precision across different SV types, sizes, and sequencing conditions.

Whole genome optical mapping reveals multiple fusion events chained by large novel sequences in cancer

The paper uses whole genome optical mapping to reveal complex chained fusion events and novel sequences in cancer genomes that are not detected by short-read sequencing.