Molecular BiologyeLifePeer-reviewed
PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1dephosphorylation by PP1-Neurabin
Roman O Fedoryshchak, Karim El-Bouri, Dhira Joshi…·Richard Treisman
The paper identifies 4E-BP and p70 S6K as substrates of PP1-Neurabin/Spinophilin holoenzymes and shows that PDZ domain interactions, not PP1 groove remodeling, determine substrate specificity.
DOI 10.7554/elife.103403