Richard Treisman

The MRTFs are required for thymocyte trafficking and Treg-mediated immune tolerance

This study shows that MRTF-SRF signaling is critical for thymocyte egress and Treg-mediated immune tolerance, leading to autoimmune phenotypes in MrtfabKOT mice.

An RPEL-based FRET sensor for G-actin

The paper introduces GASPs, FRET sensors for G-actin, and shows cytoplasmic and nuclear G-actin levels respond to cell density and focal adhesion integrity.

PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1dephosphorylation by PP1-Neurabin

The paper identifies 4E-BP and p70 S6K as substrates of PP1-Neurabin/Spinophilin holoenzymes and shows that PDZ domain interactions, not PP1 groove remodeling, determine substrate specificity.

MRTF-dependent cytoskeletal dynamics drive efficient cell cycle progression

This study shows that MRTF-SRF activity is essential for cell cycle progression, as its inactivation leads to slow proliferation, elevated SASP factors, and cytoskeletal defects.

PP1 PNUTS binds the restrictor and dephosphorylates RNA pol II CTD Ser5 to stimulate transcription termination

The paper identifies PP1 phosphatase activity in the PPWZ complex as essential for antisense transcription termination by dephosphorylating RNA pol II CTD Ser5.

Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme

The paper identifies the molecular mechanism by which Phactr1/PP1 phosphatase achieves substrate specificity through structural and phosphoproteomic analysis.