Author

Roman O Fedoryshchak

The Francis Crick InstituteORCID 0000-0003-1865-8372Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:fluorescence / live-cell microscopy· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Richard TreismaniD· 4 shared Stéphane MouilleroniD· 3 shared Abbey M. ButleriD· 1 shared Ambrosius P. SnijdersiD· 1 shared Anthony J. SaviolaiD· 1 shared Benjamin EricksoniD· 1 shared David L. BentleyiD· 1 shared Dhira JoshiiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersMolecular Biology

Richard TreismanORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Cell BiologybioRxivPreprintAug 3, 2026

An RPEL-based FRET sensor for G-actin

Roman O Fedoryshchak, Juan M. Fons, Matthew J. Renshaw, Richard Treisman

The paper introduces GASPs, FRET sensors for G-actin, and shows cytoplasmic and nuclear G-actin levels respond to cell density and focal adhesion integrity.

DOI 10.64898/2026.07.31.741674

fluorescence / live-cell microscopyexperimental assay

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Molecular BiologyeLifePeer-reviewedJun 23, 2025

PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1dephosphorylation by PP1-Neurabin

Roman O Fedoryshchak, Karim El-Bouri, Dhira Joshi…·Richard Treisman

The paper identifies 4E-BP and p70 S6K as substrates of PP1-Neurabin/Spinophilin holoenzymes and shows that PDZ domain interactions, not PP1 groove remodeling, determine substrate specificity.

DOI 10.7554/elife.103403

experimental assay

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Molecular BiologybioRxivPreprintJul 12, 2024

PP1 PNUTS binds the restrictor and dephosphorylates RNA pol II CTD Ser5 to stimulate transcription termination

Benjamin Erickson, Roman O Fedoryshchak, Nova Fong…·David L. Bentley

The paper identifies PP1 phosphatase activity in the PPWZ complex as essential for antisense transcription termination by dephosphorylating RNA pol II CTD Ser5.

8 citations

experimental assay

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Molecular BiologyeLifePeer-reviewedSep 25, 2020

Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme

Roman O Fedoryshchak, Magdalena Přechová, Abbey M. Butler…·Richard Treisman

The paper identifies the molecular mechanism by which Phactr1/PP1 phosphatase achieves substrate specificity through structural and phosphoproteomic analysis.

39 citations

protein structurestatistical model

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