Author
The Francis Crick InstituteORCID 0000-0001-7977-6298Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Wei Yee Chan, Enkai Jin, Hector Cross…·Folkert Jacobus van Werven
Yeast m6A reader Pho92 uses one helical hydrophobic interface in its disordered region to engage Caf40; a single L35A substitution halts m6A-transcript decay in meiosis.
Roman O Fedoryshchak, Karim El-Bouri, Dhira Joshi…·Richard Treisman
The paper identifies 4E-BP and p70 S6K as substrates of PP1-Neurabin/Spinophilin holoenzymes and shows that PDZ domain interactions, not PP1 groove remodeling, determine substrate specificity.
Jack P. C. Williams, Stéphane Mouilleron, Rolando Hernández Trapero…·Louise J. Walport
This study determines the crystal structure of human PADI6, revealing structural differences that suggest it lacks catalytic activity compared to other PADIs.
Benjamin Erickson, Roman O Fedoryshchak, Nova Fong…·David L. Bentley
The paper identifies PP1 phosphatase activity in the PPWZ complex as essential for antisense transcription termination by dephosphorylating RNA pol II CTD Ser5.
Roman O Fedoryshchak, Magdalena Přechová, Abbey M. Butler…·Richard Treisman
The paper identifies the molecular mechanism by which Phactr1/PP1 phosphatase achieves substrate specificity through structural and phosphoproteomic analysis.