Yevel Flores-García

This paper develops a live-attenuated Toxoplasma vaccine by knocking out DGAT1, showing it provides long-term protection against both acute and chronic toxoplasmosis.

This paper improves an anti-malaria antibody to broaden its recognition of malaria parasite proteins and enhances its protective effectiveness against diverse strains.

This study evaluates virus-like particle vaccines targeting a specific CSP epitope, showing that structural context and adjuvant combinations enhance antibody responses and sterilizing immunity against malaria.

This study infects pregnant mice with Plasmodium berghei at different gestational stages to investigate how placental malaria affects perinatal outcomes and identifies immune and hormonal changes associated with adverse effects.

This study develops a TRIO VLP vaccine targeting Anopheles mosquito salivary protein to enhance immunity against Plasmodium, showing strong antibody responses but limited protective efficacy in a malaria challenge model.

This study shows that somatic hypermutation increases cross-reactivity of anti-PfCSP antibodies by enhancing flexibility in antigen-bound complexes, but reduces serum stability.