Author

Xingyu Chen

Peking UniversityORCID 0000-0002-4550-9914Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Xingyu Chen3 papers · Institute of Vegetables and Flowers

Biology Disciplines

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Bioinformatics· 1 Immunology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:large language model· 1

Frequent Co-Authors

Fuping YouiD· 3 shared Boming KangiD· 2 shared Hanjie Liu· 1 shared Haocheng Wang· 1 shared Haoxiang Qi· 1 shared Qian WangiD· 1 shared Qinghua CuiiD· 1 shared Rui FaniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersSystems Biology

Fuping YouORCID

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3 papers

Recent·Most cited

MNS induces antiviral protection and suppresses inflammation

Y Q Zhao, Xingyu Chen, Y D Xie, Hanjie Liu, Boming Kang, Shuailong Zheng, Yuxiang Ren, Qian Wang, Fuping You, Haoxiang Qi

This study shows that MNS reduces viral infection and inflammation in cell and animal models by suppressing inflammatory pathways and altering chromatin accessibility.

Annals of Medicine · May 14, 2026Peer-reviewedSystems Biology

Betrixaban Activates cGAS and ERVs to Promote Dual Nucleic-Sensing Antiviral Immunity

Xingyu Chen, Yang Zhao, Yunfei Xie, Tianyi Liu, Haocheng Wang, Xiao Wang, Xuefei Guo, Fuping You

This paper shows Betrixaban activates cGAS and ERVs to trigger antiviral immunity through dual pathways, suggesting its repurposing as a broad-spectrum antiviral.

EMBO Molecular Medicine · Mar 23, 2026Peer-reviewedImmunology

Highly accurate prediction of broad-spectrum antiviral compounds with DeepAVC

Boming Kang, Yang Zhao, Xingyu Chen, Rui Fan, Fuping You, Qinghua Cui

This paper introduces DeepAVC, a framework using pre-trained large language models to predict broad-spectrum antiviral compounds, achieving high accuracy and identifying novel compounds with experimental validation.

bioRxiv · Feb 15, 2025 · PreprintBioinformatics