Sara Knott

Evaluating regional heritability mapping methods for identifying QTLs in a wild population of Soay sheep

The paper evaluates regional heritability mapping methods to identify QTLs in Soay sheep, finding that some methods detect new trait-associated regions not found by GWAS.

Estimating cancer risk in carriers of Lynch syndrome variants in UK Biobank

The paper estimates cancer risk in Lynch syndrome carriers using UK Biobank data, finding elevated colorectal and endometrial cancer risks but not breast cancer.

Investigating pedigree- and SNP-associated components of heritability in a wild population of Soay sheep

The paper applies a method to estimate heritability in a wild sheep population, finding that including an identity-by-descent GRM improves model fit for polygenic traits but not monogenic ones.

The impact of SNP density on quantitative genetic analyses of body size traits in a wild population of Soay sheep

This study examines how SNP density affects heritability estimates and QTL detection in Soay sheep body size traits using two SNP datasets.

SNP and Haplotype Regional Heritability Mapping (SNHap-RHM): joint mapping of common and rare variation affecting complex traits

SNHap-RHM jointly maps common and rare genetic variation affecting complex traits by combining SNP and haplotype-based genomic relationship matrices, identifying significant genomic regions for height and MDD.