Reduction of insulin/IGF-1 receptor rejuvenates immunity via positive feedback circuit
Yujin Lee, Yoonji Jung, Dae‐Eun Jeong, Wooseon Hwang, Seokjin Ham, Hae‐Eun H. Park, Sujeong Kwon, Jasmine M. Ashraf, Coleen Tara Murphy, Seung‐Jae Lee
This study shows that reducing insulin/IGF-1 receptor activity delays immunosenescence and rejuvenates immunity in C. elegans through a positive feedback circuit involving DAF-16/FOXO and HSF-1.
The Journal of Cell Biology · Feb 11, 2021Peer-reviewedGenetics