Author

Seung‐Jae Lee

Korea Advanced Institute of Science and TechnologyORCID 0000-0002-6103-156XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 3 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 4 Approach:experimental assay· 4 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Dong-Yeop LeeiD· 2 shared Stefan TaubertiD· 2 shared Yoonji JungiD· 2 shared Alexandre Zacharie KadhimiD· 1 shared Amy Fong-Yuk PooniD· 1 shared Anik MuhuriiD· 1 shared Arjumand GhaziiD· 1 shared Arshia Beigi· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersGenetics

Dong-Yeop LeeORCID

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Author profile →

4 papers

Recent·Most cited

GeneticsMolecules and CellsPeer-reviewedApr 16, 2026

Caffeine extends lifespan by enhancing lysosomal lipolysis in Caenorhabditis elegans

Hyemin Min, Eunseok Kang, Gee‐Yoon Lee…·Seung‐Jae Lee

This study shows caffeine extends lifespan in C. elegans by enhancing lysosomal lipolysis through a dietary restriction-like transcriptional program.

DOI 10.1016/j.mocell.2026.100358

C. elegansbulk RNA-seq

𝕏 PostBluesky

GeneticsThe Journal of Cell BiologyPeer-reviewedFeb 11, 2021

Reduction of insulin/IGF-1 receptor rejuvenates immunity via positive feedback circuit

Yujin Lee, Yoonji Jung, Dae‐Eun Jeong…·Seung‐Jae Lee

This study shows that reducing insulin/IGF-1 receptor activity delays immunosenescence and rejuvenates immunity in C. elegans through a positive feedback circuit involving DAF-16/FOXO and HSF-1.

40 citations

C. elegansexperimental assay

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GeneticsPLoS GeneticsPeer-reviewedDec 9, 2019

Mediator subunit MDT-15/MED15 and Nuclear Receptor HIZR-1/HNF4 cooperate to regulate toxic metal stress responses in Caenorhabditis elegans

Naomi Shomer, Alexandre Zacharie Kadhim, Jennifer M. Grants…·Stefan Taubert

This study shows that MDT-15 and HIZR-1 cooperate to regulate metal detoxification and zinc storage in C. elegans, with partial conservation in mammals.

27 citations

C. elegansexperimental assay

𝕏 PostBluesky

Developmental BiologybioRxivPreprintJul 10, 2018

C. elegans Mediator 15 permits low temperature-induced longevity via regulation of lipid and protein homeostasis

Dong-Yeop Lee, Seon Woo A. An, Yoonji Jung…·Seung‐Jae Lee

This study shows that MDT-15 regulates lipid composition and protein homeostasis to enable longevity at low temperatures in C. elegans.

DOI 10.1101/366153

C. elegansexperimental assay

𝕏 PostBluesky