Coleen Tara Murphy

The paper identifies glial cells as the gatekeepers for small RNA transport from the germline to the nervous system in C. elegans, revealing a mechanism for transgenerational epigenetic inheritance of behavior.

This study shows that pharmacologic AMPK activation with MK-8722 extends lifespan in C. elegans and improves metabolic health in aged mice.

This study shows that exposure to lysed C. elegans remains extends lifespan via distinct pathways in young and aged worms, independent of ascaroside pheromones or bacterial lysates.

This study identifies Todstoff, a novel aversive cue in C. elegans that induces necrotaxis behaviors by signaling through ASH neurons and GPCR pathways.

This study identifies SET1/COMPASS-mediated de novo transcription as a mechanism accelerating forgetting with age in C. elegans and humans.

The paper profiles single-nucleus RNA sequencing data from male and hermaphrodite C. elegans neurons to identify sex-specific and sex-shared transcriptional regulators of behavior.

This paper identifies molecular mechanisms underlying transgenerational epigenetic inheritance of pathogen avoidance in C. elegans, showing that specific small RNAs from bacteria mediate this behavior across generations.

Single-nucleus RNA sequencing of adult C. elegans neurons identifies transcriptional changes in daf-2 mutants related to chemosensation, learning, and memory.

The paper critiques Gainey et al.'s failure to replicate transgenerational epigenetic inheritance experiments in C. elegans due to methodological deviations.

The paper shows that PF15 small RNA Pfs1 induces transgenerational avoidance of PF15 in C. elegans by targeting the vab-1 Ephrin receptor gene, revealing a new bacterial sRNA/C. elegans gene target pair involved in pathogen avoidance.

The paper identifies LOAD risk genes through systems biology and shows their impact on memory function via neuronal endosomal dysfunction in C. elegans.

This study investigates the IIS/FOXO pathway's role in cognitive aging using C. elegans, finding that daf-2 mutants exhibit distinct transcriptomic changes that enhance neuronal resilience.

The paper shows a bacterial small RNA induces transgenerational learned avoidance in C. elegans, with potential maladaptive effects on beneficial bacteria.

This study identifies sex-dimorphic neuronal aging features in C. elegans males and hermaphrodites, revealing differential gene expression and X-chromosomal dysregulation associated with cognitive decline.

Activating the Gαq pathway in aged worms and mice improves memory and cognitive function, demonstrating conservation across species.

This study shows that hypodermal insulin/IGF-1 signaling regulates memory in C. elegans through non-autonomous signaling via the Notch pathway.

This study shows that piRNA pathway downregulation in the germline during mating releases Hedgehog signaling, leading to somatic aging and reduced lifespan.

The paper investigates how male sexual interactions negatively affect female and hermaphrodite lifespan in C. elegans, uncovering genes involved in male-induced demise and longevity pathways.

The paper shows that mitochondrial fission and PINK-1-mediated mitophagy are necessary for reproductive longevity in daf-2 mutants, but not in wild-type worms.

The paper introduces GAIT-GM, a Galaxy tool for multi-omics analysis, and finds a link between branched-chain amino acid metabolism and cholinergic neuron defects in a C. elegans Parkinson's disease model.

CeAid is a smartphone app that streamlines data logging for C. elegans assays using gestures and voice recognition, reducing manual effort.

This study shows that oleic acid rescues mating-induced death in C. elegans by restoring fat storage, suggesting a role for fat metabolism in uncoupling reproduction from lifespan.

The paper identifies four FDA-approved drugs, including metformin, as potential Parkinson's disease therapeutics using a high-throughput behavioral screen in C. elegans.

This study shows that reducing insulin/IGF-1 receptor activity delays immunosenescence and rejuvenates immunity in C. elegans through a positive feedback circuit involving DAF-16/FOXO and HSF-1.

The paper shows that C. elegans uses the Cer1 retrotransposon to transmit pathogen avoidance memories across generations through inter-tissue signaling.

This study shows that metabolic defects in C. elegans lead to hyperactive mitochondria and Parkinson's-like traits, with metformin improving motor function and reducing neurodegeneration.

This study identifies PQM-1 as a regulator of hypoxic survival in C. elegans by modulating lipid metabolism and oxygen consumption, with trade-offs between maternal and progeny survival.

This study shows that C. elegans uses bacterial non-coding RNAs to learn and transmit pathogenic avoidance behavior across generations.

This paper shows that CREB regulates reproductive aging in C. elegans by controlling a Hedgehog-related signaling factor, WRT-10, through the TGF-β Sma/Mab pathway in the hypodermis.

The paper identifies presynaptic mRNAs in C. elegans and shows that puf-7/8 repress memory formation by regulating mff-1.