This study identifies 31 plasma proteins and expands genetic loci associated with PCOS, highlighting metabolic and hormonal influences and polygenic risk effects on cardio-metabolic outcomes.

medRxiv · Apr 18, 2024 · PreprintGenetic & Genomic Medicine

The genetic architecture of sporadic and recurrent miscarriage

Triin Laisk, Ana Gonçalves Soares, Teresa Cruz Ferreira, Jodie N. Painter, Samantha Laber, Jonas Bačelis, Chia‐Yen Chen, Maarja Lepamets, Kuang Lin, SiYang Maggie Liu, Iona Y. Millwood, Avinash Ramu, Jennifer H. Southcombe, Marianne Andersen, Ling Yang, , Cecilia M. Lindgren

This study identifies genetic variants associated with sporadic and recurrent miscarriage through large-scale association analyses and Mendelian randomization.

bioRxiv · Mar 12, 2019 · PreprintGenetics

Large-Scale Genome-Wide Meta Analysis of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture for Different Diagnosis Criteria.

Felix R. Day, Tugce Karaderi, Michelle R. Jones, Cindy Meun, Chunyan He, Alex W. Drong, Peter Kraft, Nan Lin, Hongyan Huang, Linda Broer, Reedik Mägi, Richa Saxena, Triin Laisk, Margrit Urbanek, M. Geoffrey Hayes, , Corrine Kolka Welt

This study performs a large-scale genome-wide meta-analysis of PCOS cases and identifies genetic loci associated with PCOS and related traits, showing shared genetic architecture across different diagnostic criteria.

PLoS Genetics · Dec 19, 2018Peer-reviewedGenetics