Iona Y. Millwood

Genetic analyses of blood pressure traits in 140,000 admixed adults from Mexico City

This study conducts GWAS on blood pressure traits in 140,559 admixed Mexican adults, identifying novel genetic signals and highlighting ancestry-specific heterogeneity.

Multi-ancestry MHC-pQTL mapping reveals disease-linked HLA protein networks and shared genetic architecture

This study maps MHC-pQTL across ancestries, identifying genetic associations with plasma proteins and linking HLA genes to immune-related traits.

Copy number variant association analysis in 94,730 Chinese adults reveals loci influencing anthropometric and cardiometabolic traits

This study identifies 19 CNV associations with anthropometric and cardiometabolic traits in 94,730 Chinese adults, expanding ancestry diversity in CNV research.

Population-scale molecular reconstruction of human circadian phase from blood biomarkers

The paper infers circadian phase from blood biomarkers in UK Biobank using machine learning and defines a new construct, circadian acceleration, with genetic and environmental associations.

Phenome-wide associations of polygenic scores for schizophrenia and major depression in 100,000 Chinese adults

This study examines polygenic scores for schizophrenia and major depression in Chinese adults, finding associations with various traits and highlighting ancestry-specific genetic correlations.

Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults

This study identifies 128 BP-associated loci in Chinese adults through GWAS and shows causal links between BP traits and CVD using Mendelian randomisation.

Natural selection exerted by historical coronavirus epidemic(s): comparative genetic analysis in China Kadoorie Biobank and UK Biobank

The paper investigates historical coronavirus selection events using genetic data from China Kadoorie Biobank and UK Biobank, finding enrichment of virus-interacting genes in East Asians but not in UKB.

Genetic influences on alcohol flushing in East Asian populations

This study identifies genetic variants associated with alcohol flushing in East Asian populations and suggests self-reported flushing can be used as an instrumental variable for alcohol intake.

A High-resolution Haplotype-resolved Reference Panel Constructed from the China Kadoorie Biobank Study

The paper constructs a high-resolution haplotype-resolved reference panel from the China Kadoorie Biobank study and demonstrates its superior performance in imputing microarray data compared to existing panels.

Genotyping and population structure of the China Kadoorie Biobank

The paper reports genotyping and population structure findings from the China Kadoorie Biobank, revealing relatedness, consanguinity, and population movement patterns.

Multi-ancestry genome-wide association study improves resolution of genes, pathways and pleiotropy for lung function and chronic obstructive pulmonary disease

This study performs a multi-ancestry GWAS on lung function and COPD, identifying 559 genes and 29 pathways, and showing genetic risk scores are associated with COPD across ancestries.

Global biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts

This study evaluates polygenic risk score methods across diverse biobanks and ancestries, finding that European reference panels often yield better performance, while PRS-CS outperforms P+T for high-heritability traits.

Implicating genes, pleiotropy and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

This study identifies 118 candidate causal genes and 21 novel lipid loci on the X chromosome through a multi-ancestry meta-analysis of blood lipid levels, revealing sex-biased effects and pleiotropy with cardiovascular and hormonal traits.

Meta-analysis fine-mapping is often miscalibrated at single-variant resolution

This paper shows that meta-analysis fine-mapping is often miscalibrated due to cohort heterogeneity and introduces a QC method to identify suspicious loci.

Global Biobank Meta-analysis Initiative: powering genetic discovery across human diseases

Meta-analysis of harmonized GWAS from up to 18 biobanks (six ancestry groups) across 14 endpoints replicated 320 known loci and identified 188 apparently novel loci.

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

This paper integrates GWAS data with functional genomic datasets to identify regulatory mechanisms and causal genes underlying lipid-related traits.

Multi-ancestry GWAS of major depression aids locus discovery, fine-mapping, gene prioritisation, and causal inference

This paper conducts a multi-ancestry GWAS of major depression, identifying 190 loci and 354 genes, with findings showing increased fine-mapping power and bidirectional BMI relationship in European ancestry samples.

Trans-ancestry meta-analysis improves performance of genetic scores for multiple adiposity-related traits in East Asian populations

This paper improves genetic scores for adiposity traits in East Asian populations by using trans-ancestry meta-analysis, increasing variance explained compared to European-derived scores.

Multi-Ancestry Meta-Analysis yields novel genetic discoveries and ancestry-specific associations

This paper introduces MAMA, a method for multi-ancestry GWAS meta-analysis, which identifies novel genetic associations and improves power across populations.

Within-sibship GWAS improve estimates of direct genetic effects

In 159,701 siblings from 17 cohorts, population GWAS overstate direct effects on height, education, smoking, cognition, depressive symptoms and age at first birth; clinical traits mostly agree across models.

The transferability of lipid loci across African, Asian and European cohorts

This study assesses the transferability of lipid loci across African, Asian, and European populations, finding high consistency but also population-specific variations.

The genetic architecture of sporadic and recurrent miscarriage

This study identifies genetic variants associated with sporadic and recurrent miscarriage through large-scale association analyses and Mendelian randomization.

Lifelong genetically lowered sclerostin and risk of cardiovascular disease.

This study finds that genetically or therapeutically lowering sclerostin increases cardiovascular risk, based on genetic variant analysis and clinical trial data.

Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity

This study identifies genetic loci associated with early childhood growth phenotypes and links them to later adiposity traits, suggesting potential targets for obesity prevention.