De novo antibody discovery in human blood from full-length single B cell transcriptomics and matching haplotyped-resolved germline assemblies
John Beaulaurier, Lynn Ly, J. Andrew Duty, Carly Tyer, Christian S. Stevens, Chuan-Tien Hung, Akash Sookdeo, Alex W. Drong, Shreyas Kowdle, D. J. Turner, Sissel Juul, Scott Hickey, Benhur Lee
This study uses single-cell transcriptomics and germline haplotype assembly to discover antibodies from human blood post-MMR vaccination, showing neutralization of measles virus.
bioRxiv · Mar 26, 2024 · PreprintImmunology