Daniel Urrutia-Cabrera

This study optimizes AAV serotypes and promoters to specifically target Muller glial cells in rats, identifying ShH10Y and GFAP promoter as the most effective combination for in vivo delivery.

This study compares electrical and behavioural measures of vision in rodent models of inherited blindness, revealing that retinal dysfunction appears well before measurable vision loss.

This study optimizes AAV serotypes and promoters to specifically target Müller glial cells in rats, identifying ShH10Y and GFAP promoter as the most effective combination for in vivo delivery.

The paper uses Iso-Seq to discover novel isoform variants in human retinal cells at single-cell resolution, identifying thousands of new transcripts and differential splicing patterns.

This study evaluates RNA-targeting CRISPR-Cas13 and engineered U1 systems to reduce mis-spliced ABCA4 variants in Stargardt disease, showing significant reductions in disease-causing splice variants.

This study uses spatial transcriptomics to analyze human retinoblastoma, revealing tumor heterogeneity, cell-cell communication networks, and key signaling pathways involved in tumor progression.

This study shows that knocking out POLDIP2 in human RPE cells reduces mitochondrial superoxide levels, linking POLDIP2 to oxidative stress in AMD.

This study uses CRISPR interference to show that TMEM97 knockdown protects ARPE19 cells from oxidative stress-induced death, supporting its role in AMD pathobiology.