Keith R G Martin

Optimization of AAV tools to target Muller glial cells for retinal gene therapy

This study optimizes AAV serotypes and promoters to specifically target Muller glial cells in rats, identifying ShH10Y and GFAP promoter as the most effective combination for in vivo delivery.

Optimization of AAV tools to target Müller glial cells for retinal gene therapy

This study optimizes AAV serotypes and promoters to specifically target Müller glial cells in rats, identifying ShH10Y and GFAP promoter as the most effective combination for in vivo delivery.

Using RNA-targeting CRISPR-Cas13 and engineered U1 systems to reduce ABCA4 splice variants in Stargardt disease

This study evaluates RNA-targeting CRISPR-Cas13 and engineered U1 systems to reduce mis-spliced ABCA4 variants in Stargardt disease, showing significant reductions in disease-causing splice variants.

Immunochemical analysis of the integrin expression in retinal pigment epithelial cells

The paper analyzes integrin expression in primary rat RPE cells and the human ARPE-19 cell line using immunochemistry, finding that both express integrins, with ARPE-19 increasing expression after long-term culturing.

PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS

The paper identifies axonal PIP3 deficiency as a cause of CNS regeneration failure and shows that p110δ can restore regeneration by acting hyperactively.