Luozixian Wang

Optimization of AAV tools to target Muller glial cells for retinal gene therapy

This study optimizes AAV serotypes and promoters to specifically target Muller glial cells in rats, identifying ShH10Y and GFAP promoter as the most effective combination for in vivo delivery.

Characterising retinal function with optomotor visual performance in P23H rodent models of retinitis pigmentosa

This study compares electrical and behavioural measures of vision in rodent models of inherited blindness, revealing that retinal dysfunction appears well before measurable vision loss.

Optimization of AAV tools to target Müller glial cells for retinal gene therapy

This study optimizes AAV serotypes and promoters to specifically target Müller glial cells in rats, identifying ShH10Y and GFAP promoter as the most effective combination for in vivo delivery.

Iso-Seq enables discovery of novel isoform variants in human retina at single cell resolution

The paper uses Iso-Seq to discover novel isoform variants in human retinal cells at single-cell resolution, identifying thousands of new transcripts and differential splicing patterns.

Spatial transcriptomic profiling of human retinoblastoma

This study uses spatial transcriptomics to analyze human retinoblastoma, revealing tumor heterogeneity, cell-cell communication networks, and key signaling pathways involved in tumor progression.

Knockout of AMD-associated gene POLDIP2 reduces mitochondrial superoxide in human retinal pigment epithelial cells

This study shows that knocking out POLDIP2 in human RPE cells reduces mitochondrial superoxide levels, linking POLDIP2 to oxidative stress in AMD.