Daniel R. Plaugher

This study shows that EZH1/2 inhibition with valemetostat enhances anti-PD1 immunotherapy in lung squamous cell carcinoma by increasing MHC Class II and reprogramming neutrophils.

This study shows that inhibiting EZH2 in lung cancer enhances immunogenicity and TIL reactivity by altering the tumor microenvironment and T cell properties.

This study shows that methionine restriction reduces lung cancer progression and enhances chemotherapy response in a mouse model and human cell lines.

This study links modular restructuring in pancreatic cancer signaling networks to treatment efficacy by showing how mutation locations affect disease aggression and control.

This paper reviews techniques for controlling Boolean gene regulatory networks, comparing methods like algebraic approaches and feedback vertex sets using a T-LGL leukemia model.

The paper analyzes how changes in model parameters affect optimal control policies, time to absorption, and mixing times in Boolean models of biological systems.

This paper uses a Boolean model to study the impact of mutations in pancreatic cancer and identifies potential drug targets based on simulation and clinical data.

The paper builds a stochastic Boolean network model of pancreatic cancer microenvironment to identify control targets that can shift the gene regulatory network from a diseased to a healthy state.