Jinpeng Liu

EZH1/2 inhibition improves immunotherapy response through MHC Class II de-repression and neutrophil reprogramming

This study shows that EZH1/2 inhibition with valemetostat enhances anti-PD1 immunotherapy in lung squamous cell carcinoma by increasing MHC Class II and reprogramming neutrophils.

mTORC1-Dependent Regulation of the CCL24-CCR3 Axis Controls Granuloma Formation and Maintenance in Sarcoidosis

This study identifies mTORC1's role in regulating the CCL24-CCR3 axis, showing its impact on granuloma formation and maintenance in sarcoidosis, with therapeutic implications.

Single-Cell Analysis of Gene Regulatory Networks in the Mammary Glands of P4HA1-knockout mice

This study uses single-cell RNA sequencing and the SCENIC pipeline to analyze gene regulatory networks in P4HA1-knockout mice, identifying unique regulatory patterns in control mice linked to stem cell and inflammatory pathways.

EZH2 Inhibition Boosts Tumor Immunogenicity and TIL Reactivity in Lung Cancer

This study shows that inhibiting EZH2 in lung cancer enhances immunogenicity and TIL reactivity by altering the tumor microenvironment and T cell properties.

DIFS: Discriminative Feature Selection for Cell Clustering based on Single-Cell RNA Sequencing Data

DIFS improves cell clustering in scRNA-seq by selecting discriminative genes through a two-stage statistical framework.

Methionine Restriction Reduces Lung Cancer Progression and Increases Chemotherapy Response

This study shows that methionine restriction reduces lung cancer progression and enhances chemotherapy response in a mouse model and human cell lines.

SeqOthello: Query over RNA-seq experiments at scale

SeqOthello enables efficient querying of large RNA-seq datasets to identify known and novel fusion events with high accuracy and portability.