Cell Type-Agnostic Optical Perturbation Screening Using Nuclear In-Situ Sequencing (NIS-Seq)
Caroline I. Fandrey, Peter Konopka, Marius Jentzsch, Afraa Aqeel Zackria, Salie Maasewerd, Eicke Latz, Jonathan Leo Schmid-Burgk
The paper introduces NIS-Seq, a method for genome-scale optical perturbation screening in any nucleus-containing cell type, and demonstrates its application in identifying inflammation-related pathway components.
bioRxiv · Jan 18, 2024 · PreprintGenomics