Peter Konopka

This study shows that multiple clustered centrosomes in antigen-presenting cells enhance T cell activation by positioning near the cell center, unlike T cells where centrosomes polarize toward the immune synapse.

This paper develops AI-designed protein binders for cancer cell surface proteins, showing their effectiveness in detection and targeting through experimental validation and benchmarking of structure prediction models.

The paper shows that centrosomes in non-dividing cells can fracture under mechanical stress during cell navigation, and Dyrk3 prevents this fracturing to maintain cellular function.

The paper introduces NIS-Seq, a method for genome-scale optical perturbation screening in any nucleus-containing cell type, and demonstrates its application in identifying inflammation-related pathway components.